Alzheimer's disease (AD) is the most common form of neurodegenerative dementia.
Metabolic disorders including obesity and type 2 diabetes mellitus (T2DM) may stimulate …

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and the
most common type of dementia. A growing body of evidence has implicated …

Recent literature has pointed to the existence of inflammasome-mediated inflammatory
pathways in central nervous system (CNS) disorders and associated changes in behavior …

Parkinson's disease (PD) is a typical neurodegenerative disease and the pathological
feature of which is the death of dopamine neurons in the substantia nigra region. At present …

Inflammasomes are specialized signaling platforms critical for the regulation of innate
immune and inflammatory responses. Various NLR family members (ie, NLRP1, NLRP3 …

Neurological disorders occur in the central and peripheral nervous system and include
Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system …

Neuroinflammation is considered one of major factors in the pathogenesis of Alzheimer's
disease (AD). In particular, inflammasome activation, including NLRP3 inflammasome in …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by the loss of
dopamine neurons in the substantia nigra and the formation of Lewy bodies, which are …

The function and regulation of different heterogeneous reactive states of astrocytes in
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …

Neuroinflammation is one of the core pathological features of Alzheimer's disease (AD) as
both amyloid β (Aβ) and tau monomers and oligomers can trigger the long-term pro …