The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory
form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The …

Ischemic stroke (also called cerebral ischemia) is one of the leading causes of death and
severe disability worldwide. NLR inflammasomes play a crucial role in sensing cell damage …

Nerve injury and nerve pain are common diseases caused by neuroinflammation.
Numerous studies have shown that the activation of NLRP3 (nod-like receptor family, pyrin …

Background Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in
mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
presence of intracellular neurofibrillary tangles (NFTs) containing hyperphosphorylated tau …

Neuroinflammation and autophagy dysfunction are known to be involved in the pathological
procession of Alzheimer's disease (AD). Progesterone (PG), neuroactive steroids, exerts a …

An active role of neuroinflammation and the NLRP3 inflammasome in Alzheimer's disease
and related tauopathies is increasingly identified, supporting NLRP3 as an interesting …

Background The NLRP3 inflammasome is a sensor of specific pathogen, host and
environmental danger molecules. Upon activation NLRP3 recruits caspase-1, which cleaves …

The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …