Dichotomy in FcγRIIB deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development of autoantibodies and …
Y Kanari, A Sugahara–Tobinai, H Takahashi, M Inui… - BMC immunology, 2014 - Springer
Background The significance of a unique inhibitory Fc receptor for IgG, FcγRIIB (RIIB), in the
prevention of spontaneous production of autoantibodies remains controversial, due mainly …
prevention of spontaneous production of autoantibodies remains controversial, due mainly …
[HTML][HTML] The complex association of FcγRIIb with autoimmune susceptibility
JS Verbeek, S Hirose, H Nishimura - Frontiers in Immunology, 2019 - frontiersin.org
FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and
inflammatory responses. The observation 19 years ago that FcγRIIb−/− mice generated by …
inflammatory responses. The observation 19 years ago that FcγRIIb−/− mice generated by …
[PDF][PDF] Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis
S Bolland, JV Ravetch - Immunity, 2000 - cell.com
By virtue of its ability to couple the BCR to an inhibitory pathway, FcγRIIB can potentially
determine the fate of B cells upon IgG immune complex engagement. We now provide …
determine the fate of B cells upon IgG immune complex engagement. We now provide …
Auto-antibody production and glomerulonephritis in congenic Slamf1−/− and Slamf2−/− [B6.129] but not in Slamf1−/− and Slamf2−/− [BALB/c.129] mice
M Keszei, YE Latchman, VK Vanguri… - International …, 2011 - academic.oup.com
Several genes in an interval of human and mouse chromosome 1 are associated with a
predisposition for systemic lupus erythematosus. Congenic mouse strains that contain a 129 …
predisposition for systemic lupus erythematosus. Congenic mouse strains that contain a 129 …
Distinct and synergistic roles of FcγRIIB deficiency and 129 strain-derived SLAM family proteins in the development of spontaneous germinal centers and …
C Soni, PP Domeier, EB Wong, TN Khan, MJ Elias… - Journal of …, 2015 - Elsevier
Abstract The inhibitory IgG Fc receptor (FcγRIIB) deficiency and 129 strain-derived signaling
lymphocyte activation molecules (129-SLAMs) are proposed to contribute to the lupus …
lymphocyte activation molecules (129-SLAMs) are proposed to contribute to the lupus …
Development of murine lupus involves the combined genetic contribution of the SLAM and FcγR intervals within the Nba2 autoimmune susceptibility locus
TN Jørgensen, J Alfaro, HL Enriquez… - The journal of …, 2010 - journals.aai.org
Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune
disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic …
disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic …
The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis
AE Koh, SW Njoroge, M Feliu, A Cook, MK Selig… - Journal of …, 2011 - Elsevier
Polymorphisms in the SLAM family of leukocyte cell surface regulatory molecules have been
associated with lupus-like phenotypes in both humans and mice. The murine Slamf gene …
associated with lupus-like phenotypes in both humans and mice. The murine Slamf gene …
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility
P Boross, VL Arandhara, J Martin-Ramirez… - The Journal of …, 2011 - journals.aai.org
FcγRIIB-deficient mice generated in 129 background (FcγRIIB 129−/−) if back-crossed into
C57BL/6 background exhibit a hyperactive phenotype and develop lethal lupus. Both in …
C57BL/6 background exhibit a hyperactive phenotype and develop lethal lupus. Both in …
Fcγ RIIB and autoimmunity
M Espéli, KGC Smith, MR Clatworthy - Immunological reviews, 2016 - Wiley Online Library
Autoimmune diseases are characterized by adaptive immune responses against self‐
antigens, including humoral responses resulting in the production of autoantibodies …
antigens, including humoral responses resulting in the production of autoantibodies …
FcγRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease
K Yajima, A Nakamura, A Sugahara… - European journal of …, 2003 - Wiley Online Library
MRL. Faslpr/lpr mice, a model for systemic lupus erythematosus (SLE) and arthritis in
humans, have a Fas mutation that results in spontaneous development of systemic …
humans, have a Fas mutation that results in spontaneous development of systemic …