Introduction of heterologous anti–glomerular basement membrane antiserum (nephrotoxic
serum, NTS) into presensitized mice triggers the production of IgG anti-NTS antibodies that …

The F1cross between SWR and NZB mice, SNF1, develops severe immune complex
glomerulonephritis, in a similar manner to humans with systemic lupus erythematosus (SLE) …

Objective The BXSB. Yaa mouse strain is a model of systemic lupus erythematosus that is
dependent on duplication of the Toll‐like receptor 7 gene. The objective of this study was to …

Affinity for DNA and cross-reactivity with renal antigens are associated with enhanced renal
pathogenicity of lupus autoantibodies. In addition, certain IgG subclasses are enriched in …

Objective To characterize the subclass composition of IgG deposited in lupus glomeruli, to
examine its relationship to allelic polymorphisms of IgG receptors (Fcγ receptors [FcγR]), and …

FcγRIIB is a potent lupus susceptibility gene as demonstrated by the observation that mice
deficient in this molecule develop spontaneous antinuclear antibodies (ANA) and fatal …

The Fc receptor I for IgA (FcαRI) down-regulates humoral immune responses and modulates
the risk of autoimmunity. This study aimed to investigate whether FcαRI targeting can affect …

Engagement of immunoglobulin-binding receptors (FcγR) on leukocytes and other cell types
is one means by which immunoglobulins and immune complexes activate effector cells. One …

Genetic loci on New Zealand Black (NZB) chromosomes 1 and 13 play a significant role in
the development of lupus-like autoimmune disease. We have previously shown that …

Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility
loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a …