Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice
K Honjo, Y Kubagawa, Y Suzuki, M Takagi… - International …, 2014 - academic.oup.com
Abstract The IgM-Fc receptor (FcμR) is involved in IgM homeostasis as evidenced by
increased pre-immune serum IgM and natural auto-antibodies of both IgM and IgG isotypes …
increased pre-immune serum IgM and natural auto-antibodies of both IgM and IgG isotypes …
The onset of nephritis in the (NZB× SWR) F1 murine model for systemic lupus erythematosus correlates with an increase in the ratio of CD4 to CD8 T lymphocytes …
CJ Knupp, AH Ũner, AH Tatum, J Gavalchin - Clinical immunology and …, 1992 - Elsevier
An idiotypically related family of nephritogenic antibodies (IdLNF1) has been shown to be
important in the pathogenesis of autoimmune glomerulonephritis in the (NZB× SWR) F1 …
important in the pathogenesis of autoimmune glomerulonephritis in the (NZB× SWR) F1 …
Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB‐deficient C57BL/6 mice
S Kawano, Q Lin, H Amano, T Kaneko… - European journal of …, 2013 - Wiley Online Library
We previously established an I g GF c receptor IIB (F cγ RIIB)‐deficient C 57 BL/6 (B 6)‐
congenic mouse strain (KO 1), which spontaneously develops rheumatoid arthritis (RA), but …
congenic mouse strain (KO 1), which spontaneously develops rheumatoid arthritis (RA), but …
FcγRIIB, FcγRIIIB, and systemic lupus erythematosus
HA Niederer, MR Clatworthy… - Annals of the New …, 2010 - Wiley Online Library
The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the
deposition of immune complexes in organs such as the kidney. This occurs as a result of …
deposition of immune complexes in organs such as the kidney. This occurs as a result of …
A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody‐mediated immune responses
AL Thaller, F Jönsson, O Fiquet, S Marie… - European Journal of …, 2023 - Wiley Online Library
Human immune system (HIS) mice provide a model to study human immune responses in
vivo. Currently available HIS mouse models may harbor mouse Fc Receptor (FcR) …
vivo. Currently available HIS mouse models may harbor mouse Fc Receptor (FcR) …
c-Rel gain in B cells drives germinal center reactions and autoantibody production
M Kober-Hasslacher, H Oh-Strauß… - The Journal of …, 2020 - Am Soc Clin Investig
Single-nucleotide polymorphisms and locus amplification link the NF-κB transcription factor
c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the …
c-Rel to human autoimmune diseases and B cell lymphomas, respectively. However, the …
Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo
A Baerenwaldt, A Lux, H Danzer… - Proceedings of the …, 2011 - National Acad Sciences
Maintenance of immunological tolerance is crucial to prevent development of autoimmune
disease. The production of autoantibodies is a hallmark of many autoimmune diseases and …
disease. The production of autoantibodies is a hallmark of many autoimmune diseases and …
Comment on “Development of murine lupus involves the combined genetic contribution of the SLAM and FcγR intervals within the Nba2 autoimmune susceptibility …
D Choubey, R Panchanathan, H Shen… - The Journal of …, 2010 - journals.aai.org
The conclusion by Jørgensen et al.(1) that the Ifi200-cluster genes within the Nba2 locus are
dispensable for ANA production is not supported by experimental data (see below). The …
dispensable for ANA production is not supported by experimental data (see below). The …
RANTES deficiency attenuates autoantibody-induced glomerulonephritis
C Xie, K Liu, Y Fu, X Qin, G Jonnala, T Wang… - Journal of clinical …, 2011 - Springer
Experimental autoimmune nephritis in mice and spontaneous lupus nephritis are both
associated with elevated expression of several chemokines in the kidneys. Nevertheless …
associated with elevated expression of several chemokines in the kidneys. Nevertheless …
FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization
A Qiu, A Miller, FD Zotti, M Santhanakrishnan… - Frontiers in …, 2022 - frontiersin.org
Passive immunization with anti-D can prevent maternal alloimmunization to RhD thereby
preventing hemolytic disease of the fetus and newborn. Unexpectedly, anti-D fails in some …
preventing hemolytic disease of the fetus and newborn. Unexpectedly, anti-D fails in some …