Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-
targets based on their ligand binding sites. Concurrent developments in systems biology …

Motivation Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a
mechanistic representation of biological perturbation over different layers of biological …

In the dynamic landscape of targeted therapeutics, drug discovery has pivoted towards
understanding underlying disease mechanisms, placing a strong emphasis on molecular …

Gene signatures of drug-induced toxicity are of broad interest, but they are often identified
from small-scale, single-time point experiments, and are therefore of limited applicability. To …

Exposure of cells or organisms to chemicals can trigger a series of effects at the regulatory
pathway level, which involve changes of levels, interactions, and feedback loops of …

Identification of signaling pathways that are functional in a specific biological context is a
major challenge in systems biology, and could be instrumental to the study of complex …

The ability to map causal interactions underlying genetic control and cellular signaling has
led to increasingly accurate models of the complex biochemical networks that regulate …

Capturing the effects of exposure in a specific target organ is a major challenge in risk
assessment. Exposure to cigarette smoke (CS) implicates the field of tissue injury in the lung …

In the last decade, network approaches have transformed our understanding of biological
systems. Network analyses and visualizations have allowed us to identify essential …

Quantitative systems pharmacology aims at systematizing, in a model‐based manner, the
integration of systems biology and pharmacology in an effort to rationalize the process of …