A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

W Checkley, AC White, D Jaganath… - The Lancet Infectious …, 2015 - thelancet.com
Cryptosporidium spp are well recognised as causes of diarrhoeal disease during
waterborne epidemics and in immunocompromised hosts. Studies have also drawn …

Towards a vaccine for Cryptococcus neoformans: principles and caveats

K Datta, L Pirofski - FEMS yeast research, 2006 - academic.oup.com
In the Damage-response framework of microbial pathogenesis, infectious diseases are one
outcome of a host-microorganism interaction in a susceptible host. In cryptococcal disease …

An update on Cryptococcus among HIV-infected patients

T Warkentien… - International journal of …, 2010 - journals.sagepub.com
Cryptococcus remains an important opportunistic infection in HIV patients despite
considerable declines in prevalence during the highly active antiretroviral therapy era. This …

[HTML][HTML] Challenges and prospects for a Cryptosporidium vaccine

JR Mead - Future Microbiology, 2010 - Future Medicine
Editorial Mead do not know how much cross-protection develops between
genotypes/species, the role the initial dose plays in establishing long-term memory cell …

[HTML][HTML] Insights into the Mechanisms of Protective Immunity against Cryptococcus neoformans Infection Using a Mouse Model of Pulmonary Cryptococcosis

KL Wozniak, S Ravi, S Macias, ML Young… - PloS one, 2009 - journals.plos.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
pneumonia and meningoencephalitis in immune compromised individuals. Previous studies …

Cryptococcal meningitis

L Tugume, K Ssebambulidde, J Kasibante… - Nature Reviews …, 2023 - nature.com
Cryptococcus neoformans and Cryptococcus gattii species complexes cause
meningoencephalitis with high fatality rates and considerable morbidity, particularly in …

Are macrophages the heroes or villains during cryptococcosis?

J Rudman, RJ Evans, SA Johnston - Fungal Genetics and Biology, 2019 - Elsevier
Cryptococcus infections represents a major healthcare burden, with over 200,000 cases
globally a year and even with treatment, mortality remains as high as 80%. There is a clear …

[HTML][HTML] Cryptococcal virulence in humans: Learning from translational studies with clinical isolates

HR De Sousa, S Frazão, GP Oliveira Júnior… - Frontiers in Cellular …, 2021 - frontiersin.org
Cryptococcosis, an invasive mycosis caused by Cryptococcus spp, kills between 20% and
70% of the patients who develop it. There are no vaccines for prevention, and treatment is …

Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Preventing deaths from cryptococcal meningitis: from bench to bedside

M Roy, T Chiller - Expert review of anti-infective therapy, 2011 - Taylor & Francis
Cryptococcal meningitis (CM), a fungal disease caused by Cryptococcus spp., is the most
common form of meningitis and a leading cause of death among persons with HIV/AIDS in …