Aims: Synaptic deficits are known to underlie the cognitive dysfunction seen in Alzheimer's
disease (AD). Generation of reactive oxygen species (ROS) by β-amyloid has also been …

Generation of reactive oxygen species (ROS) causes cellular oxidative damage and has
been implicated in the etiology of Alzheimer's disease (AD). In contrast, multiple lines of …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Aims: Reactive oxygen species (ROS) generated during Alzheimer's disease (AD)
pathogenesis through multiple sources are implicated in synaptic pathology observed in the …

Learning and memory storage are the fundamental activities of the brain. Aberrant
expression of synaptic molecular markers has been linked to memory impairment in AD …

Impaired Akt1 signaling is observed in neurodegenerative diseases, including Parkinson׳ s
disease (PD). In PD models oxidative modification of Akt1 leads to its dephosphorylation …

Significance: Alzheimer disease (AD) is an all-too-common condition in the aging
population. However, aging does not automatically equal neurodegeneration and memory …

Although the basis of Alzheimer's disease (AD) etiology remains unknown, oxidative stress
(OS) has been recognized as a prodromal factor associated to its progression. OS refers to …

Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer's
disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role …

This review is focused on the possible causes of mitochondrial dysfunction in AD, underlying
molecular mechanisms of this malfunction, possible causes and known consequences of …