Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the
embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the …

Expression of bcl-w, a close relative of bcl-2 is essential for male fertility in mice. Although
the initial wave of spermatogenesis in bcl-w−/− mice proceeds normally until 3–4 weeks of …

Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice
that are mutant for Bclw display progressive and nearly complete testicular degeneration …

Anti-apoptotic members of the Bcl-2 family, such as Bcl-w, maintain cell viability by
preventing the activation of the cell death effectors, the caspases. Gene targeting …

To explore physiological roles of BCL-W, a prosurvival member of the BCL-2 protein family,
we generated transgenic (TG) mice overexpressing Bcl-w driven by a chicken β-actin …

To identify genes required for mammalian spermatogenesis, we screened lines of mutant
mice created using a retroviral genetrap system1 for male infertility. Homozygous ROSA41 …

Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

Since the cloning of the bcl-2 gene in 1985, considerable progress has been made in
elucidating the function of Bcl-2 and related proteins in controlling apoptosis. Although much …

In germ cells, the function of which is to form the next generation, apoptotic cell death occurs
during development, as in the case of somatic cells. In this study, we show that Bcl-x …

During normal spermatogenesis, more than half of the germ cells undergo apoptosis, but the
physiological significance and molecular mechanisms of this programmed cell death are …