The effect of kepone on the biliary excretion of [14C] imipramine (IMP) was studied using
isolated perfused rat liver preparations obtained from control and kepone-pretreated …

Effect of pre-exposure to the pesticide mirex on hepatic uptake, metabolism, and biliary
excretion of the tricyclic antidepressant, imipramine (IMP), was studied by using isolated …

Hepatic excretory function of Kepone (chlordecone)-preexposed (10, 50, 150 ppm in daily
ration for 15 days) male rats was examined in conjunction with hepatic mitochondrial Mg2+ …

Male Sprague-Dawley rats were treated with mirex, po, at 0, 5, 10, and 50 mg/kg/day in 0.4
ml of corn oil for 3 days. Forty-eight hours after the last treatment, the biliary excretion of …

The effect of pre-expose to hexachlorobenzene (HCB), toxaphene (TX) or DDT (100 ppm in
the diet for 8 days in each case) on the excretory function of the bile was investigated using …

Isolated perfused rat liver preparations were utilized to study the drug-induced modification
of biliary excretion of [14C] 4-chlorobiphenyl (1-CB) and [14C] 2, 4, 5-2′, 4′, 5 …

After intraperitoneal administration of imipramine (IP) to rats with bile fistula, a large part of
the material is excreted with the bile. The different types, their concentrations and their …

Piperine, a major active component of black and long peppers, has been reported to
enhance drug bioavailability. The present studies were aimed at understanding the …

The metabolism of chlorpromazine (CPZ), imipramine (IP), and imipramine-N-oxide (IPNO)
was studied in microsomal preparations of various rat tissues in vitro and in the isolated …

Aim: Genipin, a metabolite of geniposide, is reported to stimulate the insertion of multidrug
resistance protein 2 (Mrp2) in the bile canalicular membrane, and to cause choleresis by …