Enhanced de novo lipogenesis (DNL), an adult hepatic adaption, is seen with high
carbohydrate or low-fat diets. We hypothesized that ad libitum intake after prenatal calorie …

We studied glucose metabolic adaptations in the intrauterine growth-restricted (IUGR) rat
offspring to decipher glucose homeostasis in metabolic programming. Glucose futile cycling …

Intrauterine growth restriction (IUGR) leads to obesity, glucose intolerance, and type 2
diabetes mellitus in the adult. To determine the mechanism (s) behind this “metabolic …

Intrauterine growth restriction (IUGR) results in dysregulated glucose homeostasis and
adiposity in the adult. We hypothesized that with aging, these perturbations will wane, and …

The purpose of this investigation was to assess the influence of calorie restriction (CR)
alone, higher-protein/lower-carbohydrate intake alone, and combined CR higher …

Maternal caloric restriction during late gestation reduces birth weight, but whether long-term
adverse metabolic outcomes of intra-uterine growth retardation (IUGR) are dependent on …

Moderate maternal calorie restriction during lactation in rats provides certain protection
against obesity in adult offspring. Hence, we used this model with 20% calorie restriction to …

A mismatch between fetal and postnatal environment can permanently alter the body
structure and physiology and therefore contribute later to obesity and related disorders, as …

Neonatal overnutrition results in accelerated development of high-fat diet (HFD)-induced
metabolic defects in adulthood. To understand whether the increased susceptibility was …

Clinical studies have reported beneficial effects of a maternal low glycaemic index (GI) diet
on pregnancy and neonatal outcomes, but the impact of the diet on the offspring in later life …