Immune phenomena are believed to play a key role in the pathogenesis of tissue damage in
Crohn's disease and ulcerative colitis. 1 2 Although some of the immunological …

Crohn's disease (CD) is a chronic intestinal inflammatory disorder characterized by aberrant
mucosal Th1 cell activation and production of IL-12, the major Th1-driving factor. The T cell …

Summary Interleukin‐23 (IL‐23) plays an essential role in driving intestinal pathology in
experimental models of both T‐cell‐dependent and innate colitis. Furthermore, genome …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory disorders of the
gastrointestinal tract that share clinical and pathological characteristics. The most accredited …

The cytokine interleukin 15 (IL-15, a protein of 114 amino acids) was first discovered due to
IL-2-like stimulatory actions on T cells. 1 2 The heterotrimeric IL-15 receptor comprises the b …

Background It has been suggested that Crohn's disease (CD) is associated with an
exaggerated T-helper 1 cytokine response manifested by increased production of interleukin …

Cytokines play an important role in the pathology of inflammatory bowel disease by
determining the nature of the mucosal immune response. One way of establishing whether …

The cytokine responses characterizing the inflammatory bowel diseases are the key
pathophysiologic elements that govern the initiation, evolution, and, ultimately, the resolution …

BACKGROUND & AIMS: During the pathogenesis of Crohn's disease (CD), interleukin (IL)-
12, a cytokine produced by mucosal CD14+ monocyte-like cells, promotes tissue-damaging …

Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor
repertoire and a Th1-like profile of cytokine production, are responsible for macrophage …