In the prevaccine era pertussis and diphtheria were responsible for significant morbidity and
mortality in children. In the United States of America more than 125,000 cases of diphtheria …

Pertussis is a serious disease for children in all countries, but it is more severe in the
developing world. Disease incidence, complication rates and case fatality rates are highest …

Pertussis remains a major cause of morbidity and mortality, particularly in infants and young
children, and despite the availability of vaccines and pertinent national and international …

Pertussis continues to be a major public health problem in both developing and developed
countries. Data on exact burden and incidence of pertussis in the developing countries …

Available data indicate that pertussis remains an important disease during infancy and
childhood, particularly among those who are inadequately immunized. Over the past 15 …

Pertussis causes nearly 300 000 deaths in children every year. Most deaths take place in
developing countries, but the infection remains a priority everywhere. Pertussis vaccination …

Although tetanus and diphtheria have become rare in developed countries, pertussis is still
endemic in some developed countries. These are vaccine-preventable diseases and …

A diphtheria and tetanus toxoid two-component acellular pertussis vaccine (DTaP),
consisting of 25 μg glutaraldehyde-detoxified pertussis toxin (PT) and 25 μg native …

Pertussis vaccination of infants has dramatically reduced disease, complications and deaths
in infancy and early childhood. But there is still a major public health challenge—to deal with …

The control of pertussis remains a worldwide concern. Little has been documented about its
epidemiology in Africa. The authors have studied pertussis in a prospective cohort of …