Spontaneous duplication of the mammalian genome occurs in approximately 1% of
fertilizations. Although one or more whole genome duplications are believed to have …

Despite the fact that spontaneous tetraploidy is a rare phenomenon in mice, such embryos
may be produced experimentally by a variety of means, though only a very limited degree of …

Tetraploid mice prepared by electrofusion develop for up to 14 days in utero. The embryos
are essentially normal save that the forebrain and its associated tissues fail to develop …

ABSTRACT A small proportion (about 17%) of experimentally produced tetraploid
blastocysts are capable of postimplantation development in the randomly bred Q strain of …

First cleavage divisions were analyzed, after chromosome banding, in 321 zygotes
recovered from superovulated, outbred ICR mice 33–35 h after injection of human chorionic …

Spontaneous aneuploidy in the mouse is uncommon, but specific mating schemes have
been developed that produce aneuploid conceptuses at high frequencies. The most …

Tetraploid mouse embryos were produced by electrofusion at the 2-cell stage, cultured
overnight, and aggregated with normal diploid embryos to produce tetraploid↔ diploid (4n↔ …

Tetraploid (4n) mouse embryos die at variable developmental stages. By examining 4n
embryos from F2 hybrid and outbred mice, we show that 4n developmental potential is …

Many questions related to the development and the phenotypic expression of trisomy (Ts)
are amenable to systematic investigation in a mouse model that allows the induction of Ts 1 …

Previous studies have shown that tetraploid (4n) cells rarely contribute to the derivatives of
the epiblast lineage of mid-gestation 4n↔ 2n mouse chimeras. The aim of the present study …