Harnessing genetic differences between cancerous and noncancerous cells offers a
strategy for the development of new therapies. Extrapolating from yeast genetic interaction …

Synthetic lethality strategies for cancer therapy exploit cancer-specific genetic defects to
identify targets that are uniquely essential to the survival of tumor cells. Here we show …

Mutations that cause chromosome instability (CIN) in cancer cells produce “sublethal”
deficiencies in an essential process (chromosome segregation) and, therefore, may …

DNA replication and repair are critical processes for all living organisms to ensure faithful
duplication and transmission of genetic information. Flap endonuclease 1 (Fen1), a structure …

Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient
DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme …

Functional deficiency of the FEN1 gene has been suggested to cause genomic instability
and cancer predisposition. We have identified a group of FEN1 mutations in human cancer …

Abstract Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that
has a critical role in maintaining human genome stability. FEN1 mutations have been …

DNA damage repair plays a key role in maintaining genomic stability and integrity. Flap
endonuclease 1 (FEN1) is a core protein in the base excision repair (BER) pathway and …

Somatic mutations causing chromosome instability (CIN) in tumors can be exploited for
selective killing of cancer cells by knockdown of second-site genes causing synthetic …

Given the broad utility of humanized yeast to model and study human biology, a reference
set of human genes that can replace cognate yeast genes and operate in yeast is needed …