The molecular basis of human heart failure is unknown. Alterations in calcium homeostasis
have been observed in failing human heart muscles. Intracellular calcium-release channels …

Calcium (Ca2+) ions are second messengers in signaling pathways in all types of cells.
They regulate muscle contraction, electrical signals which determine the cardiac rhythm and …

Calcium (Ca2) ions are second messengers in numerous sig-naling pathways in all cell
types. 1 In the heart, Ca2 regulates muscle contraction, electrical signals that determine the …

Calcium release from intracellular stores is the signal generated by numerous regulatory
pathways including those mediated by hormones, neurotransmitters and electrical activation …

The molecular basis for the systolic and diastolic dysfunction characteristic of end-stage
heart failure in humans remains poorly understood. It has been proposed that both abnormal …

Background Regulation of intracellular calcium levels is known to activate signal
transduction pathways, leading to well-defined patterns of gene expression. Methods and …

During the last decade there was accumulating evidence Ž. that alterations of excitation-
contraction EC coupling may play a critical role in the pathophysiology of myocardial failure …

There is accumulating evidence that disturbed calcium homeostasis may play a key role in
the pathophysiology of human heart failure. Because disturbed calcium handling could …

The ryanodine and inositol 1, 4, 5-trisphosphate (IP3) receptors have previously been found
to be intracellular Ca2+ release channels characterized by their large size and 4-fold …

Ca2+ release from intracellular stores occurs through two main classes of intracellular
membrane channel; the sarcoplasmic reticulum (SR) Ca2+-release channel/ryanodine …