The circulatory system distributes blood flow to each tissue and transports oxygen and
nutrients. Peripheral circulation is required to maintain the physiological function in each …

Hypoxia, the decline of tissue oxygen stress, plays a role in mediating cellular processes.
Cardiovascular disease, relatively widespread with increased mortality, is closely correlated …

Cardiac function is required for blood circulation and systemic oxygen delivery. However,
the heart has intrinsic oxygen demands that must be met to maintain effective contractility …

Oxygen is essential for living organisms. Molecular oxygen binds to hemoglobin and is
delivered to every organ in the body. In several cardiovascular diseases or anemia, local …

Atherosclerosis is by far the most frequent underlying cause of coronary artery disease,
carotid artery disease and peripheral arterial disease, and is associated with high morbidity …

Atherosclerosis is a highly prevalent disease that can significantly increase the risk of major
vascular events, such as myocardial or cerebral infarctions. The anoxemia theory states that …

Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular
diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main …

Hypoxia is a state where oxygen availability/delivery is below the level necessary to
maintain physiological oxygen tension for a particular tissue. It is well-established that when …

Cardiovascular disease (CVD) accounts for the largest number of deaths worldwide,
necessitating the development of novel treatments and prevention strategies. Given the …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …