Global cerebral ischemia (GCI) commonly occurs in the elderly. Subcortical white matter
lesions and oligodendrocyte (OLG) loss caused by cerebral ischemia have been implicated …

Clinical studies examining the potential of anti-inflammatory agents, specifically of
minocycline, as a treatment for depression has shown promising results. However …

Depression and anxiety have been reported as the major neuropsychiatric consequences
following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms …

Background and Purpose—Minocycline, a semisynthetic tetracycline antibiotic, has been
reported to ameliorate brain injury and inhibit microglial activation after focal cerebral …

Rationale The role of glial cells, especially microglia and astrocytes, in neuroinflammation
and cognition has been studied intensively. Lipopolysaccharide (LPS), a commonly used …

Background Altered neuronal connectivity in peri-infarct tissue is an important contributor to
both the spontaneous recovery of neurological function that commonly develops after stroke …

Methods The rat model with vascular cognitive impairment was established by permanent
bilateral common carotid artery occlusion (BCCAO). The observing time-points were …

Intracerebral hemorrhage (ICH) is a devastating disease worldwide with increasing
mortality. The present study investigated whether minocycline was neuroprotective and …

Accumulating evidences have suggested that anxiety-like behavior and impairment of
learning and memory are key symptoms of post-traumatic stress disorder (PTSD), and …

Previous studies have suggested that minocycline can attenuate cognitive deficits in animal
models of conditions such as Alzheimer's disease and cerebral ischemia through inhibiting …