New drugs for the treatment of complicated intra-abdominal infections in the era of increasing antimicrobial resistance

LS Syue, YH Chen, WC Ko, PR Hsueh - International journal of …, 2016 - Elsevier
The continuing increase in multidrug-resistant organisms (MDROs) worldwide has created
new challenges in treating complicated intra-abdominal infections (cIAIs). A number of novel …

[HTML][HTML] New antimicrobial options for the management of complicated intra-abdominal infections

S Leone, G Damiani, I Pezone, ME Kelly… - European Journal of …, 2019 - Springer
Complicated intra-abdominal infections (cIAIs) are a common cause of morbidity and
mortality in surgical patients. Optimal management of cIAI requires early source control in …

Complicated intra-abdominal infections: the old antimicrobials and the new players

YR Lee, D McMahan, C McCall, GK Perry - Drugs, 2015 - Springer
Complicated intra-abdominal infections (cIAIs) are an important cause of morbidity and
mortality worldwide. They are diagnosed when the initial abdominal organ infection has …

Current strategies for the treatment of complicated intraabdominal infections

LP Skrupky, BR Tellor, JE Mazuski - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Complicated intraabdominal infections (cIAIs) are a common cause of infection-
related morbidity and mortality in hospitalized patients and present many challenges unique …

Ceftolozane/tazobactam and ceftazidime/avibactam for the treatment of complicated intra-abdominal infections

KJ Goodlet, DP Nicolau, MD Nailor - Therapeutics and Clinical …, 2016 - Taylor & Francis
Complicated intra-abdominal infections (cIAI) represent a large proportion of all hospital
admissions and are a major cause of morbidity and mortality in the intensive care unit …

Comparing novel antibiotics and carbapenems for complicated intra-abdominal infections: A systematic review and meta-analysis of randomized controlled trials

TYT Chen, CK Hsu, SC Shih, TS Weng, HJ Tang… - International Journal of …, 2023 - Elsevier
Background Carbapenem-sparing antibiotics are needed urgently for patients with
complicated intra-abdominal infections (cIAIs). Although several novel antibiotics–novel β …

Ceftolozane/tazobactam plus metronidazole for complicated intra-abdominal infections in an era of multidrug resistance: results from a randomized, double-blind …

J Solomkin, E Hershberger, B Miller… - Clinical Infectious …, 2015 - academic.oup.com
Background. Increasing antimicrobial resistance among pathogens causing complicated
intra-abdominal infections (cIAIs) supports the development of new antimicrobials …

IGNITE4: results of a phase 3, randomized, multicenter, prospective trial of eravacycline vs meropenem in the treatment of complicated intraabdominal infections

JS Solomkin, J Gardovskis, K Lawrence… - Clinical Infectious …, 2019 - academic.oup.com
Background Increasing antimicrobial resistance among pathogens that cause complicated
intraabdominal infections (cIAIs) supports the development of new antimicrobials …

[HTML][HTML] Eravacycline: a review in complicated intra-abdominal infections

LJ Scott - Drugs, 2019 - Springer
Eravacycline (Xerava™), a novel fully synthetic fluorocycline, consists of the tetracyclic core
scaffold with unique modifications in the tetracyclic D ring; consequently, it exhibits potent in …

Eravacycline: a new treatment option for complicated intra-abdominal infections in the age of multidrug resistance

JS Solomkin, A Sway, K Lawrence, M Olesky… - Future …, 2019 - Future Medicine
Aim: Recently approved for use in complicated intra-abdominal infection, eravacycline is a
novel fluorocycline with broad spectrum of activity against resistant Gram-negative …