Systemic approaches to the study of a biological cell or tissue rely increasingly on the use of
context-specific metabolic network models. The reconstruction of such a model from high …

Genome-scale metabolic networks have been reconstructed for several organisms. These
metabolic networks provide detailed information about the metabolism inside the cells …

Background Constraint-based analysis of genome-scale metabolic models has become a
key methodology to gain insights into functions, capabilities, and properties of cellular …

Background The availability of genome sequences for many organisms enabled the
reconstruction of several genome-scale metabolic network models. Currently, significant …

Background Human tissues perform diverse metabolic functions. Mapping out these tissue-
specific functions in genome-scale models will advance our understanding of the metabolic …

Background Genome-scale metabolic reconstructions have been recognised as a valuable
tool for a variety of applications ranging from metabolic engineering to evolutionary studies …

Genome-scale metabolic reconstructions have proven to be valuable resources in
enhancing our understanding of metabolic networks as they encapsulate all known …

Network reconstructions are a common denominator in systems biology. Bottom–up
metabolic network reconstructions have been developed over the last 10 years. These …

Background Metabolic network reconstructions formalize our knowledge of metabolism.
Gaps in these networks pinpoint regions of metabolism where biological components and …

Human metabolism involves thousands of reactions and metabolites. To interpret this
complexity, computational modeling becomes an essential experimental tool. One of the …