Abstract Pendrin (SLC26A4) is a Cl−/anion exchanger expressed in the epithelium of
inflamed airways where it is thought to facilitate Cl− absorption and HCO 3− secretion …

Pendrin is an anion exchanger whose mutations are known to cause hearing loss. However,
recent data support the linkage between pendrin expression and airway diseases, such as …

The expression and function of the anion exchanger pendrin (SLC26A4) was thought to be
limited mainly to the inner ear, kidney and thyroid. Recent data indicates that pendrin is also …

The transport of chloride and bicarbonate across epithelia controls the pH and volume of the
intracellular and luminal fluids, as well as the systemic pH and vascular volume. The anion …

Bicarbonate facilitates mucin unpacking and bacterial killing; however, its transport
mechanisms in the airways are not well understood. cAMP stimulates anion efflux through …

In most HCO 3−-secreting epithelial tissues, SLC26 Cl−/HCO 3− transporters work in concert
with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the …

Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic
Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete …

Abstract Background/Aims: Pendrin is a Cl-/I-/HCO3-exchanger playing a fundamental role
in controlling blood pressure and airway function, therefore representing an attractive target …

Asthma exacerbations can be triggered by viral infections or allergens. The Th2 cytokines IL-
13 and IL-4 are produced during allergic responses and cause increases in airway epithelial …

Objective: The aim of this study is to evaluate the role of pendrin in acute lung injury
(ALI)/acute respiratory distress syndrome (ARDS) and to explore whether pendrin …