Introduction: A large proportion of the coumarin dose variability is explained by
environmental factors and by common genetic variants in the VKORC1 and CYP2C9 genes …

The narrow therapeutic range and wide interpatient variability in dose requirement make
anticoagulation response to coumarin derivatives unpredictable. As a result, patients require …

Anticoagulant therapy with coumarin derivatives is often sub-or supra-therapeutic, resulting
in an increased risk of thromboembolic events or hemorrhage, respectively …

Coumarin derivates are oral anticoagulants commonly prescribed for treatment and
prevention of thromboembolism. Due to a small therapeutic index and large inter-and …

Background: Coumarin anticoagulants (acenocoumarol, phenprocoumon, and warfarin) are
generally used for the prevention of stroke in patients with atrial fibrillation or for the therapy …

The cytochrome P450 (CYP) 4F2 gene is known to influence mean coumarin dose. The aim
of the present study was to undertake a meta‐analysis at the individual patients level to …

During the last decade genetic factors affecting coumarin therapy have been extensively
investigated. The most important genes appear to be CYP2C9 and VKORC1, and different …

Coumarins are effective drugs for treatment and prevention of thromboembolic events.
However, their use requires a balancing act between the chance of underdosing which …

This is a comment on" A randomized trial of genotype-guided dosing of acenocoumarol and
phenprocoumon." N Engl J Med. 2013 Dec 12; 369 (24): 2304-12. This is a comment on" A …

When Lemuel Gulliver travels to Brobdingnag in Gulliver's Travels [1], he describes the 60-
foot-tall giants who surround him. The reader is treated to detailed descriptions from the …