Objective: Inflammation underlies the pathological basis of most diseases. Substance-P is a
key mediator that participates in various inflammatory processes and painful conditions …

Substance 48/80 (condensation product of p-methoxy-N-methylphenethylamine with
formaldehyde) is known to cause release of histamine and serotonin from the granules in …

Nerve growth factor (NGF) is a polypeptide essential for the development and function of
neurones in the CNS and PNS. It elicits several biological effects on neuronal and …

Objective and Design: We investigated the role of neuronal and mast cell histamine in the
analgesic effect of clomipramine.¶ Subjects: Male Sprague-Dawley rats (4–6 weeks old) …

The murine strains differ in the number of peritoneal mast cells. Degranulation of peritoneal
mast cells by single injection of compound 48/80 (1.2 mg/kg) followed by zymosan-induced …

Studied the effects of repeated treatment with Compound 48/80 on pain perception and
morphine analgesia in rats. Compound 48/80 was administered twice a day for 7 days (1 …

Basophils and mast cells produce several cytokines which are released after their activation
and may regulate the secretion of many inflammatory mediators. However, it has been …

Objective and design: DhL, a lactone isolated from Artemisia douglasiana, prevents
gastrointestinal damage elicited by necrosis-inducing agents and exhibits antiinflammatory …

We studied the in vitro effects of FPL-52694 [5-(2-hydroxypropoxyl)-8-propyl-4-oxo-4H-
benzopyran-2-carboxylic acid Na] on histamine release from rat peritoneal mast cells. These …

Introduction All known antihistaminics may affect several inflammatory events, including
chemotaxis, the survival of eosinophils, and the release of chemokines and cytokines from …