Malignant growth of cells is often characterized by disorganization of tissue structure,
abnormal blood vessel development, and insuffi cient vascular supply. As a consequence …

The purpose of the meeting was to exchange information on spheroid culture methods and
to review the role of spheroids in cancer research. Techniques and results presented at this …

During the last three decades multicellular spheroids of both normal and malignant cells
have been used as model systems for studying three-dimen sional growth and differentiation …

A poorly vascularized solid tumour can have many properties that complicate the situation
for drug treatment. The deficient blood vessel support will lead to regions consisting of well …

This chapter focuses on the use of multicellular tumor spheroids as a model for studies of
drug effects and recently published results. A general growth pattern can be described for …

Cellular aggregates have been used in developmental biology and in experimental cancer
research for several decades. Spherical aggregates of malignant cells, ie multicellular tumor …

Threedimensional culture systems, pioneered with the development by Moscona (1961) of
the technology to culture embryonic cells in reaggregate structures and by Sutherland and …

The growth of tumour cells as three‐dimensional multicellular spheroids in vitro has led to
important insights in tumour biology, since properties of the in vivo‐tumour such as …

Human tumour cells from surgical material were grown as multicellular spheroids. In 16 out
of 20 culturesspheroids with a diameter of more than Z 5 0 p could be observed. In 6 out of …

Abnormal vascularization of malignant tumors is associated with the development of
microregions of heterogeneous cells and environments. Experimental models such as …