Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and
discovered to resemble stages in neurogenesis. One tumor class displaying neuronal …

Despite recent therapeutic advances, gliomas, in particular the most frequent and malignant
glioblastoma, remain devastating tumors and need a better molecular characterization to …

Glioblastomas are invasive and aggressive tumors of the brain, generally considered to
arise from glial cells. A subset of these cancers develops from lower-grade gliomas and can …

Identification of distinct molecular subtypes is a critical challenge for cancer biology. In this
study, we used Affymetrix high-density oligonucleotide arrays to identify the global gene …

The modern clinical practice of neuro-oncology is dependent on accurate tumor
classification. No variable predicts prognosis more precisely, and classification is also the …

Glioblastomas,(grade 4 astrocytomas), are aggressive primary brain tumors characterized
by histopathological heterogeneity. High-resolution sequencing technologies have shown …

The development of targeted treatment strategies adapted to individual patients requires
identification of the different tumor classes according to their biology and prognosis. We …

Glioblastoma is classified into two subtypes on the basis of clinical history:“primary
glioblastoma” arising de novo without detectable antecedent disease and “secondary …

K. Masui, TF Cloughesy and PS Mischel (2012) Neuropathology and Applied
Neurobiology38, 271–291 Molecular pathology in adult high‐grade gliomas: from molecular …

Neoplastic transformation occurs in all glial cell types of the human nervous system,
producing a wide variety of clinico‐pathological entities and morphological variants …