Cell death, particularly that of tubule epithelial cells, contributes critically to the
pathophysiology of kidney disease. A body of evidence accumulated over the past 15 years …

Acute kidney injury (AKI) is a common and severe clinical condition with a heavy healthy
burden around the world. In spite of supportive therapies, the mortality associated with AKI …

The term acute tubular necrosis was thought to represent a misnomer derived from
morphological studies of human necropsies and necrosis was thought to represent an …

Understanding nephron loss is a primary strategy for preventing CKD progression. Death of
renal tubular cells may occur by apoptosis during developmental and regenerative …

Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Acute tubular necrosis causes a loss of renal function, which clinically presents as acute
kidney failure (AKI). The biochemical signaling pathways that trigger necrosis have been …

The nephrons of the kidney are independent functional units harboring cells of a low
turnover during homeostasis. As such, physiological renal cell death is a rather rare event …

Abstract Background/Aims: Regulated necrosis is an expanding research field with
important implications for acute kidney injury (AKI). A focused review of the evolving …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …

Acute kidney injury (AKI) frequently occurs in patients with chronic kidney disease (CKD)
and in turn, may cause or accelerate CKD. Therapeutic options in AKI are limited and mostly …