Biochemical and structural analysis of membrane proteins often critically depends on the
ability to overexpress and solubilize them. To identify properties of eukaryotic membrane …

Historically, the task of determining the structure of membrane proteins has been hindered
by experimental difficulties associated with their lipid-embedded domains. Here, we provide …

Abstract The field of Membrane Protein Structural Biology has grown significantly since its
first landmark in 1985 with the first three-dimensional atomic resolution structure of a …

Detergents play a significant role in structural and functional characterisation of integral
membrane proteins (IMPs). IMPs reside in the biological membranes and exhibit a great …

Given the central roles of membrane proteins in cellular processes ranging from nutrient
uptake to cell− cell communication, as well as the importance of these proteins as drug …

Membrane proteins are pivotal players in biological processes. In order to understand how a
membrane protein works, it is important to purify the protein to fully characterize it …

Protein purification efforts for structural genomics will focus on automation for the readily-
expressed proteins, and process development for the more difficult ones, such as membrane …

At the time when the first membrane-protein crystal structure was determined, crystallization
of these molecules was widely perceived as extremely arduous. Today, that perception has …

The production of membrane proteins of high purity and in satisfactory yields is crucial for
biomedical research. Due to their involvement in various cellular processes, membrane …

The importance of membrane proteins in biological systems is indisputable; however, their
amphipathic nature makes them difficult to analyze. In this study, the most popular …