Chagas disease is caused by the parasite Trypanosoma cruzi and affects approximately
eight million individuals in the developing world; it is also classified as a neglected tropical …

Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1, 2, 3-triazolic para-
naphthoquinones, five nor-β-lapachone-based 1, 2, 3-triazoles, and several other …

Chagas disease (CD), caused by Trypanosoma cruzi, affects approximately eight million
individuals in Latin America and is emerging in nonendemic areas due to the globalisation …

The current treatment of Chagas disease is based on the use of two drugs, nifurtimox (Nfx)
and benznidazole (Bnz), both of which present limited efficacy in the chronic stage of the …

In this study, a series of 22 pre-synthesized 7-chloro-4-amino (oxy) quinoline derivatives
was assayed in vitro as potential antichagasic agents. A primary screening against …

In continuation our effort to research the chemical space of aryloxy-naphthoquinones as
potential anti-Chagas agents, we synthesized nine derivatives and these compounds were …

Chagas disease is a potentially life-threatening and neglected tropical disease caused by
Trypanosoma cruzi. One of the most important challenges related to Chagas disease is the …

Chagas disease (CD) is a neglected tropical disease of worldwide health concern, caused
by the flagellate protozoan Trypanosoma cruzi (T. cruzi), endemic in Latin America and …

Sixteen 5, 6-dihydro-2H-pyran-2-ones were evaluated in in vitro assay against
trypomastigotes forms of Trypanosoma cruzi, the causative agent of Chagas' disease. A …

Chagas disease affects around 8 million people worldwide and its treatment depends on
only two nitroheterocyclic drugs, benznidazole (BZD) and nifurtimox (NFX). Both drugs have …