Despite ongoing efforts, the current treatment for Chagas disease is still unsatisfactory,
mainly because of the severe side effects and variable efficacy of the available …

Chagas' disease is an important parasitic illness caused by the flagellated protozoan
Trypanosoma cruzi. The disease affects nearly 17 million individuals in endemic areas of …

Chagas disease (CD), a neglected tropical disease caused by Trypanosoma cruzi, remains
a serious public health problem in several Latin American countries. The available …

Chagas disease continues to be one of the main parasitic diseases in Latin America.
Despite the fact that it was discovered more than 100 years ago, no suitable pharmacologic …

Two series of diaryl-tetrahydrofuran and-furan were synthesised and screened for anti-
trypanosomal activity against trypomastigote and amastigote forms of Trypanosoma cruzi …

Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is a serious public health problem.
Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious …

Severe infections with potentially fatal outcomes are caused by parasites from the genera
Trypanosoma and Leishmania (class Kinetoplastea). The diseases affect people of remote …

An antikinetoplastid pharmacomodulation study was conducted at position 6 of the 8-
nitroquinolin-2 (1 H)-one pharmacophore. Fifteen new derivatives were synthesized and …

Quinones are attractive pharmacological scaffolds for developing new agents for the
treatment of different transmissible and non-transmissible human diseases due to their …

Atom‐based bilinear indices and linear discriminant analysis are used to discover novel
trypanosomicidal compounds. The obtained linear discriminant analysis‐based quantitative …