Two-year clinical efficacy trial with dose variations of a vas deferens injectable contraceptive for the male

SK Guha, G Singh, A Srivastava, HC Das, JC Bhardwaj… - Contraception, 1998 - Elsevier
Contraceptive action of a single intra–vas deferens injection of a specific preparation of
styrene maleic anhydride (SMA) dissolved in dimethyl sulphoxide, forming a drug given the …

Phase II clinical trial of a vas deferens injectable contraceptive for the male

SK Guha, G Singh, S Ansari, S Kumar, A Srivastava… - Contraception, 1997 - Elsevier
Following up on an earlier clinical trial demonstrating the safety of an intra-vas deferens
injection of a contraceptive drug named Risug, comprised of styrene maleic anhydride …

Phase I clinical trial of an injectable contraceptive for the male

SK Guha, G Singh, S Anand, S Ansari, S Kumar, V Koul - Contraception, 1993 - Elsevier
Earlier studies on the rat and the monkey had demonstrated that an injection of styrene
maleic anhydride (SMA) in a solvent vehicle of dimethyl sulphoxide (DMSO) into the lumen …

[PDF][PDF] A proton NMR study of the effect of a new intravasal injectable male contraceptive RISUG on seminal plasma metabolites

U Sharma, K Chaudhury, NR Jagannathan… - REPRODUCTION …, 2001 - academia.edu
There is a need to develop a suitable male contraceptive for population control programmes.
The current unavailability of an ideal male contraceptive is due to the lack of one or more …

Safety evaluation of a male injectable antifertility agent, styrene maleic anhydride, in rats

N Sethi, RK Srivastava, RK Singh - Contraception, 1989 - Elsevier
Injection of a polymer, styrene maleic anhydride (SMA), into the lumen of the vas deferens of
rats, was observed to have effective and reversible contraception. The safety evaluation of …

RISUG® as a male contraceptive: journey from bench to bedside

B Khilwani, A Badar, AS Ansari, NK Lohiya - Basic and Clinical Andrology, 2020 - Springer
Even after decades of research men still lack reliable and reversible contraceptive methods
comparable to female methods of contraception. Traditional methods of male contraception …

A short-term evaluation of semen and accessory sex gland function in phase III trial subjects receiving intravasal contraceptive RISUG

SP Chaki, HC Das, MM Misro - Contraception, 2003 - Elsevier
Following the intravasal injection of a new male contraceptive RISUG (reversible inhibition
of sperm under guidance) in volunteers, routine semen analysis, semen biochemistry and …

RISUG™(reversible inhibition of sperm under guidance)–an antimicrobial as male vas deferens implant for HIV free semen

SK Guha - Medical hypotheses, 2005 - Elsevier
HIV transmission from the male to the female is a major health problem. A hypothesis
proposing an intra vas deferens implant of an antimicrobial compound to prevent the …

Preclinical toxicity study of a male injectable antifertility agent (styrene maleic anhydride) in rhesus monkeys, Macaca mulatta

N Sethi, RK Srivastava, D Nath… - Journal of medical …, 1991 - Wiley Online Library
Polymer styrene maleic anhydride dissolved in dimethyl sulphoxide was injected
intravasally to rhesus monkeys at the dose levels of 100 mg, 250 mg, and 500 mg in each …

Chronic toxicity of styrene maleic anhydride, a male contraceptive, in rhesus monkeys (Macaca mulatta)

N Sethi, RK Srivastava, RK Singh, GS Bhatia, N Sinha - Contraception, 1990 - Elsevier
A newly developed male contraceptive, styrene maleic anhydride (SMA), was injected in the
vas deferens of male rhesus monkeys for safety evaluation at the dose of 100 mg …