Background Markers of cerebrovascular disease are common in dementia, and may be
present before dementia onset. However, their clinical relevance in midlife adults at risk of …

Background Considerable overlap exists between the risk factors of dementia and cerebral
small vessel disease (SVD). However, studies remain limited to older cohorts wherein …

Objectives: Cerebral small vessel disease (SVD) is commonly observed among elderly
individuals with cognitive impairment and has been recognized as a vascular contributor to …

Importance It remains unclear if and how associations between cerebral small-vessel
disease and Alzheimer disease (AD) pathology lead to cognitive decline and dementia …

Cerebral small vessel disease (SVD) and inflammation are increasingly recognized as key
contributors to Alzheimer's disease (AD), although the timing, trajectory, and relation …

Aims: To investigate the contribution of vascular risk factors (VRFs), vascular diseases (VDs)
and white matter lesions (WMLs) to the progression of mild cognitive impairment (MCI) to …

Background: Cerebral small vessel disease (SVD) and neuropsychiatric symptoms (NPS)
independently increase the risk of cognitive decline. While their co-existence has been …

Background: Small vessel disease (SVD) and Alzheimer's disease (AD) frequently coexist;
however, it remains unclear how they collectively affect cognition. Objective: We investigated …

Importance Cerebrovascular disease (CVD) and Alzheimer disease are significant causes of
cognitive impairment in the elderly. However, few studies have evaluated the relationship …

In order to prevent the onset of vascular dementia (VaD) in aging individuals, it is critical to
detect clinically relevant vascular and systemic pathophysiological changes to signal the …