Associations among vascular risk factors, neuroimaging biomarkers, and cognition: preliminary analyses from the Multi‐Ethnic Study of Atherosclerosis (MESA)

SN Lockhart, CL Schaich, S Craft… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

[HTML][HTML] Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Vascular cognitive impairment and dementia: An early career researcher perspective

NCBS Silva, O Bracko, AR Nelson… - Alzheimer's & …, 2022 - Wiley Online Library
The field of vascular contributions to cognitive impairment and dementia (VCID) is evolving
rapidly. Research in VCID encompasses topics aiming to understand, prevent, and treat the …

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

J Li, YJ Wang, M Zhang, ZQ Xu, CY Gao, CQ Fang… - Neurology, 2011 - AAN Enterprises
Objective: Growing evidence suggests that vascular risk factors (VRF) contribute to cognitive
decline. The aim of this study was to investigate the impact of VRF on the conversion from …

Vascular cognitive impairment: a preventable component of dementia

MR Azarpazhooh, V Hachinski - Handbook of Clinical Neurology, 2019 - Elsevier
For many decades during the 20th century, the common belief was that the slow
strangulation of the brains' blood supply from hardening of the brain arteries led to chronic …

Past antihypertensive medication use is associated with lower levels of small vessel disease and lower Aβ plaque stage in the brains of older individuals

AJ Affleck, PS Sachdev… - … and Applied Neurobiology, 2023 - Wiley Online Library
Aims This study assesses the association of antihypertensive medication use on the
severities of neuropathological cerebrovascular disease (CVD excluding lobar infarction) in …

Cerebral small vessel disease, medial temporal lobe atrophy and cognitive status in patients with ischaemic stroke and transient ischaemic attack

F Arba, T Quinn, GJ Hankey, M Ali… - European journal of …, 2017 - Wiley Online Library
Background and purpose Small vessel disease (SVD) and Alzheimer's disease (AD) are two
common causes of cognitive impairment and dementia, traditionally considered as distinct …

[HTML][HTML] Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol

AGW van Norden, KF de Laat, RAR Gons… - BMC neurology, 2011 - Springer
Background Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans
of elderly people and is related to vascular risk factors and cognitive and motor impairment …

[HTML][HTML] Regional White Matter Hyperintensities and Alzheimer's Disease Biomarkers Among Older Adults with Normal Cognition and Mild Cognitive Impairment

P Newton, J Tchounguen, C Pettigrew… - Journal of …, 2023 - content.iospress.com
Background: Alzheimer's disease (AD) frequently co-occurs with other brain pathologies.
Recent studies suggest there may be a mechanistic link between AD and small vessel …

[HTML][HTML] METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for …

M Dichgans, J Wardlaw, E Smith, V Zietemann… - Alzheimer's & …, 2016 - Elsevier
Dementia is a global problem and major target for health care providers. Although up to 45%
of cases are primarily or partly due to cerebrovascular disease, little is known of these …