Frontotemporal dementia (FTD) is the second most common dementia before 65 years of
age. Haploinsufficiency in the progranulin (GRN) gene accounts for 10% of all cases of …

Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in
social and emotional function. Heterozygous loss-of-function mutations in GRN, the …

Frontotemporal dementia (FTD) is typified by behavioral and cognitive changes manifested
as altered social comportment and impaired memory performance. To investigate the …

Background: Loss-of-function progranulin gene (GRN) mutations have been identified as the
major cause of frontotemporal lobar degeneration with transactive response (TAR) DNA …

Mutations in progranulin gene (GRN) are one of the major causes of autosomal dominant
Frontotemporal Lobar Degeneration (FTLD). Progranulin displays anti-inflammatory …

Progranulin haploinsufficiency is a common cause of familial frontotemporal dementia
(FTD), but the role of progranulin in the brain is poorly understood. To investigate the role of …

Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin
(PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is …

Progranulin haploinsufficiency causes frontotemporal dementia with tau-negative, ubiquitin-
positive neuronal inclusion pathology. In this study, we showed that progranulin-deficient …

Frontotemporal dementia (FTD) is the most common neurodegenerative disorder in
individuals under age 60 and has no treatment or cure. Because many cases of FTD result …

Loss-of-function mutations in GRN cause frontotemporal dementia (FTD) with transactive
response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid …