The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation
and is implicated in carcinogenesis. It contains multiple conserved chromatin-associated …

KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …

Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …

Histone posttranslational modifications are important components of epigenetic regulation.
One extensively studied modification is the methylation of lysine residues. These …

Histone methylation is one of the most important chromatin posttranslational modifications. It
has a range of influences on nuclear functions including epigenetic inheritance …

Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di-and
trimethylation marks, plays critical roles in controlling transcription and chromatin …

The lysine-specific histone demethylase 1A (KDM1A) was the first demethylase to challenge
the concept of the irreversible nature of methylation marks. KDM1A, containing a flavin …

Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …

The histone lysine demethylase KDM4 subfamily, comprised of four members (A, B, C, and
D), play critical roles in controlling transcription, chromatin architecture and cellular …

Histone H3K4 methylation has been linked to transcriptional activation. KDM5A (also known
as RBP2 or JARID1A), a member of the KDM5 protein family, is an H3K4 demethylase …