The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers
BJ Klein, L Piao, Y Xi, H Rincon-Arano, SB Rothbart… - Cell reports, 2014 - cell.com
The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation
and is implicated in carcinogenesis. It contains multiple conserved chromatin-associated …
and is implicated in carcinogenesis. It contains multiple conserved chromatin-associated …
[HTML][HTML] Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential
RM Labbé, A Holowatyj, ZQ Yang - American journal of …, 2014 - ncbi.nlm.nih.gov
KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …
Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis
J Yoo, GW Kim, YH Jeon, JY Kim, SW Lee… - … & Molecular Medicine, 2022 - nature.com
Distinct epigenetic modifiers ensure coordinated control over genes that govern a myriad of
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …
cellular processes. Growing evidence shows that dynamic regulation of histone methylation …
The role of the histone demethylase KDM4A in cancer
L Guerra-Calderas, R González-Barrios, LA Herrera… - Cancer genetics, 2015 - Elsevier
Histone posttranslational modifications are important components of epigenetic regulation.
One extensively studied modification is the methylation of lysine residues. These …
One extensively studied modification is the methylation of lysine residues. These …
[HTML][HTML] Histone demethylase lysine demethylase 5B in development and cancer
M Han, W Xu, P Cheng, H Jin, X Wang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Histone methylation is one of the most important chromatin posttranslational modifications. It
has a range of influences on nuclear functions including epigenetic inheritance …
has a range of influences on nuclear functions including epigenetic inheritance …
[HTML][HTML] Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer
J Hou, J Wu, A Dombkowski, K Zhang… - American journal of …, 2012 - ncbi.nlm.nih.gov
Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di-and
trimethylation marks, plays critical roles in controlling transcription and chromatin …
trimethylation marks, plays critical roles in controlling transcription and chromatin …
KDM1A microenvironment, its oncogenic potential, and therapeutic significance
The lysine-specific histone demethylase 1A (KDM1A) was the first demethylase to challenge
the concept of the irreversible nature of methylation marks. KDM1A, containing a flavin …
the concept of the irreversible nature of methylation marks. KDM1A, containing a flavin …
Diverse functions of KDM5 in cancer: Transcriptional repressor or activator?
Y Ohguchi, H Ohguchi - Cancers, 2022 - mdpi.com
Simple Summary Aberrations in epigenetic modulators have been widely identified in
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
cancer; therefore, these modulators are attractive targets for cancer treatment. KDM5 is an …
[HTML][HTML] Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer
Q Ye, A Holowatyj, J Wu, H Liu, L Zhang… - American journal of …, 2015 - ncbi.nlm.nih.gov
The histone lysine demethylase KDM4 subfamily, comprised of four members (A, B, C, and
D), play critical roles in controlling transcription, chromatin architecture and cellular …
D), play critical roles in controlling transcription, chromatin architecture and cellular …
Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex
G Nishibuchi, Y Shibata, T Hayakawa… - Journal of Biological …, 2014 - ASBMB
Histone H3K4 methylation has been linked to transcriptional activation. KDM5A (also known
as RBP2 or JARID1A), a member of the KDM5 protein family, is an H3K4 demethylase …
as RBP2 or JARID1A), a member of the KDM5 protein family, is an H3K4 demethylase …