During the past decade, our understanding of the pathophysiology of coronary artery
disease (CAD) has undergone a remarkable evolution. We review here how these advances …

In the past, we believed that atherosclerosis gradually and progressively led to the complete
occlusion of an artery, thereby causing acute coronary events. However, we now understand …

Contemporary clinical and laboratory data have challenged our classical concepts of the
pathogenesis of the acute coronary syndromes. Indeed, several independent lines of clinical …

About half of the patients presenting with myocardial infarction do not have the classic risk
factors. This finding has stimulated a search for other factors that may be responsible and …

Ischemic heart disease, a consequence of coronary atherosclerosis, is the leading cause of
death in the United States and developing countries. The clinical manifestations of coronary …

The concept of the vulnerable plaque has generated much interest and stimulated a quest to
develop diagnostic modalities to identify potentially unstable atherosclerotic plaques …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Despite improvements in interventional and pharmacological therapy for atherosclerotic
disease, it is still the leading cause of death in the developed world. Hence, there is a need …

Until recently, most envisaged atherosclerosis as a bland arterial collection of cholesterol,
complicated by smooth muscle cell accumulation. According to that concept, endothelial …

Inflammation is now recognized as being pivotal in the pathogenesis of atherosclerosis. This
review highlights key concepts in our current understanding of the role of inflammation in the …