The interaction between the vulnerable atherosclerotic plaque and thrombus formation, a
process referred to as atherothrombosis, is the cornerstone of acute coronary syndromes …

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Observations on human and experimental atherosclerosis, biomarker studies, and now a
large-scale clinical trial support the operation of immune and inflammatory pathways in this …

Atherosclerosis is a chronic, inflammatory disease of the arterial wall that underlies many of
the common causes of cardiovascular morbidity and mortality, including myocardial …

Eroded or disrupted atherosclerotic plaques act as a substrate for thrombosis, leading to
ischemic coronary artery and cerebrovascular disease. Plaques vary greatly in composition …

Abstract Concepts of atherogenesis have evolved considerably with time. Early animal
experiments showed that a cholesterol-rich diet could induce fatty lesion formation in …

Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of
cardiovascular ischaemic events. The evolution of vascular disease involves a combination …

Inflammation plays a pivotal role in both the development of atherosclerosis and the acute
activation of the vascular wall with consequent local thrombosis and vasoconstriction (with …

Coronary atherosclerosis is a chronic inflammatory disease that can lead to varying degrees
of blood flow obstruction and a common pathophysiological basis of cardiovascular disease …

Despite advanced understanding of the biology of atherosclerosis, coronary heart disease
remains the leading cause of death worldwide. Progress has been challenging as half of the …