The concept that inflammation participates pivotally in the pathogenesis of atherosclerosis
and its complications has gained considerable attention, but has not yet entered clinical …

Coronary artery disease (CAD) and acute myocardial infarction (AMI) are inflammatory
pathologies, involving interleukins (ILs), such as IL-1β, IL-6 and tumor necrosis factor (TNF) …

Inflammation plays a pivotal role in all stages of atherogenesis, from foam cell to plaque
formation to rupture and ultimately to thrombosis. Insight gained from recent basic and …

Well into the 21st century, we still triage acute myocardial infarction on the basis of the
presence or absence of ST-segment elevation, a century-old technology. Meanwhile, we …

During atherosclerosis, lipid-rich plaques are formed in large-and medium-sized arteries,
which can reduce blood flow to tissues. This situation becomes particularly precarious when …

Despite substantial gains in the prevention and treat-ment of acute myocardial infarction,
many atherothrombotic events occur among individuals without readily apparent risk factors …

▪ Abstract New insights into atherosclerosis, the most common disease affecting coronary
arteries, may change therapeutic strategies from largely symptomatic to causal …

Despite the multifactorial nature of atherosclerosis, substantial evidence has established
inflammation as an often surreptitious, yet critical and unifying driving force which promotes …

There is a common misperception in the cardiology community that most acute coronary
events arise from ruptures of mildly stenotic plaques. This notion has emanated from …

Evidence from a broad range of studies demonstrates that atherosclerosis is a chronic
disease that, from its origins to its ultimate complications, involves inflammatory cells (T cells …