The role of aldehyde dehydrogenase 2 in cardiovascular disease
J Zhang, Y Guo, X Zhao, J Pang, C Pan… - Nature Reviews …, 2023 - nature.com
Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …
ALDH2 and cardiovascular disease
CH Chen, JCB Ferreira, D Mochly-Rosen - … : From Alcohol Metabolism to …, 2019 - Springer
Abstract Aldehyde dehydrogenase 2 (ALDH2) is a non-cytochrome P450 mitochondrial
aldehyde oxidizing enzyme. It is best known for its role in the metabolism of acetaldehyde, a …
aldehyde oxidizing enzyme. It is best known for its role in the metabolism of acetaldehyde, a …
ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications
Alcoholic cardiomyopathy is manifested as cardiac hypertrophy, disrupted contractile
function and myofibrillary architecture. An ample amount of clinical and experimental …
function and myofibrillary architecture. An ample amount of clinical and experimental …
Aldehyde dehydrogenase-2 as a therapeutic target
M Kimura, A Yokoyama, S Higuchi - Expert opinion on therapeutic …, 2019 - Taylor & Francis
ABSTRACT Introduction: Aldehyde dehydrogenase-2 (ALDH2) is a main contributor of the
alcohol elimination process. Functional polymorphism in the ALDH2 gene and its inactive …
alcohol elimination process. Functional polymorphism in the ALDH2 gene and its inactive …
ALDH2 Glu504Lys polymorphism and susceptibility to coronary artery disease and myocardial infarction in East Asians: a meta-analysis
J Gu, L Li - Archives of medical research, 2014 - Elsevier
Background and Aims Emerging evidences have shown that the Glu504Lys variant in
ALDH2 gene may greatly reduce the ability of ALDH2 to metabolize acetaldehyde, which …
ALDH2 gene may greatly reduce the ability of ALDH2 to metabolize acetaldehyde, which …
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells
M Yang, Y Wang, B Han, B Yang, Y Qiang… - Acta Pharmacologica …, 2018 - nature.com
Abstract Aldehyde dehydrogenase 2 (ALDH2) is a key mitochondrial enzyme in the
metabolism of aldehydes and may have beneficial cardiovascular effects for conditions such …
metabolism of aldehydes and may have beneficial cardiovascular effects for conditions such …
[PDF][PDF] Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea
Alcohol consumption is a serious health issue in Korea in terms of the amount consumed
and the behavior related to its consumption. Aldehyde dehydrogenase 2 (ALDH2) is a key …
and the behavior related to its consumption. Aldehyde dehydrogenase 2 (ALDH2) is a key …
Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis
H Han, H Wang, Z Yin, H Jiang, M Fang, J Han - Gene, 2013 - Elsevier
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the major
enzymes responsible for alcohol metabolism in humans. Emerging evidences have shown …
enzymes responsible for alcohol metabolism in humans. Emerging evidences have shown …
A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2* 2 variant
ER Gross, VO Zambelli, BA Small… - Annual review of …, 2015 - annualreviews.org
Asian Americans are one of the fastest-growing populations in the United States. A relatively
large subset of this population carries a unique loss-of-function point mutation in aldehyde …
large subset of this population carries a unique loss-of-function point mutation in aldehyde …
East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing …
Y Mizuno, E Harada, S Morita, K Kinoshita… - Circulation, 2015 - Am Heart Assoc
Background—Coronary spastic angina (CSA) is a common disease among East Asians,
including Japanese. The prevalence of alcohol flushing syndrome associated with deficient …
including Japanese. The prevalence of alcohol flushing syndrome associated with deficient …
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