Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease
JL Anderson, S Knight, HT May, BD Horne… - The American Journal of …, 2013 - Elsevier
Lipoprotein (a)(Lp [a]) has gained attention as a heritable coronary artery disease (CAD) risk
factor and therapeutic target. Two genetic variants in the LPA gene have been reported to …
factor and therapeutic target. Two genetic variants in the LPA gene have been reported to …
A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk
T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
Lipoprotein (a) and long-term cardiovascular risk in a multi-ethnic pooled prospective cohort
Abstract Background Lipoprotein (a)(Lp [a]) is a causal genetic risk factor for atherosclerotic
cardiovascular disease (ASCVD). There are limited long-term follow-up data from large US …
cardiovascular disease (ASCVD). There are limited long-term follow-up data from large US …
Lipoprotein (a) as a potential causal genetic risk factor of cardiovascular disease: a rationale for increased efforts to understand its pathophysiology and develop …
S Tsimikas, JL Hall - Journal of the American College of Cardiology, 2012 - jacc.org
Recent published studies have provided increasing evidence that lipoprotein (a)[Lp (a)] may
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …
be a potential causal, genetic, independent risk factor for cardiovascular disease (CVD). Lp …
Genetic variants associated with Lp (a) lipoprotein level and coronary disease
R Clarke, JF Peden, JC Hopewell… - … England Journal of …, 2009 - Mass Medical Soc
Background An increased level of Lp (a) lipoprotein has been identified as a risk factor for
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
coronary artery disease that is highly heritable. The genetic determinants of the Lp (a) …
Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week
S Tsimikas, SM Marcovina - Journal of the American College of Cardiology, 2022 - jacc.org
This study reviews ancestral differences in the genetics of the LPA gene, risk categories of
elevated lipoprotein (a)[Lp (a)] as defined by guidelines, ancestry-specific Lp (a) risk …
elevated lipoprotein (a)[Lp (a)] as defined by guidelines, ancestry-specific Lp (a) risk …
Association of LPA variants with risk of coronary disease and the implications for lipoprotein (a)-lowering therapies: a Mendelian randomization analysis
Importance Human genetic studies have indicated that plasma lipoprotein (a)(Lp [a]) is
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …
causally associated with the risk of coronary heart disease (CHD), but randomized trials of …
[HTML][HTML] Structure, function, and genetics of lipoprotein (a)
K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …
Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …
G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …