Since endothelial dysfunction may significantly contribute to the pathophysiology of
hypertension and its complications, its modification seems to be a very attractive means to …

Essential hypertension is associated with endothelial dysfunction, which is caused mainly by
the production of oxygen-free radicals that can destroy nitric oxide (NO), and impair its …

The benefits of treating hypertension in terms of reduction of morbidity and mortality are well
established. However, it is debatable whether this benefit is derived entirely from the effects …

Essential hypertension is characterized by endothelial dysfunction due to reduced
availability of nitric oxide (NO) secondary to increased generation of oxygen-free radicals …

A large body of evidence indicates that patients with essential hypertension are
characterized by endothelial dysfunction mediated by an impaired NO availability secondary …

The endothelium plays a crucial role in the pathogenesis of cardiovascular disease.
Endothelial function is attenuated by the presence of different well known cardiovascular risk …

Thirty-six years have passed since the seminal article by Furchgott and Zawadzki [1],
suggesting the existence of an endothelium-derived relaxing factor in arteries, was …

Essential hypertension is associated with impaired endothelium-dependent vasodilation
and is caused mainly by production of oxygen free radicals that can destroy nitric oxide …

Endothelial cells are a rich source of a variety of vasoactive substances, which either cause
vasodilation or vasoconstriction. Important endothelium-derived vasodilators are …

Strategically located between the circulating blood and the vascular smooth muscle,
endothelial cells release numerous vasoactive substances regulating the function of …