Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but
provide limited insight into the genomic diversity within tumours. Here we developed a …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in …

Genomic analysis provides insights into the role of copy number variation in disease, but
most methods are not designed to resolve mixed populations of cells. In tumours, where …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

The sequencing of cancer genomes may enable tailoring of therapeutics to the underlying
biological abnormalities driving a particular patient's tumor. However, sequencing-based …

Metastasis is the main cause of death for patients with breast cancer. Many studies have
characterized the genomic landscape of breast cancer during its early stages. However …

Our knowledge of copy number evolution during the expansion of primary breast tumours is
limited,. Here, to investigate this process, we developed a single-cell, single-molecule DNA …

Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy …

The elucidation of breast cancer subgroups and their molecular drivers requires integrated
views of the genome and transcriptome from representative numbers of patients. We present …

Recent studies have documented frequent evolution of clones carrying common cancer
mutations in apparently normal tissues, which are implicated in cancer development …