A substantial proportion of tumors consist of genotypically distinct subpopulations of cancer
cells. This intratumor genetic heterogeneity poses a substantial challenge for the …

Genome sequencing of cancers often reveals mosaics of different subclones present in the
same tumour,–. Although these are believed to arise according to the principles of somatic …

Recent advances in next generation sequencing,,, have made it possible to precisely
characterize all somatic coding mutations that occur during the development and …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen
receptor, progesterone receptor and ERBB2 gene amplification, represent approximately …

Somatic mutations drive the development of cancer and may contribute to ageing and other
diseases,. Despite their importance, the difficulty of detecting mutations that are only present …

Aneuploidy is a hallmark of breast cancer; however, knowledge of how these complex
genomic rearrangements evolve during tumorigenesis is limited. In this study, we developed …

How cell-to-cell copy number alterations that underpin genomic instability in human cancers
drive genomic and phenotypic variation, and consequently the evolution of cancer, remains …

Cancer evolution involves cycles of genomic damage, epigenetic deregulation, and
increased cellular proliferation that eventually culminate in the carcinoma phenotype. Early …