A key mutational process in cancer is structural variation, in which rearrangements delete,
amplify or reorder genomic segments that range in size from kilobases to whole …

Cancer develops through a process of somatic evolution,. Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the
basis of the presence of mutations in protein-coding regions. By contrast, much less is …

Cancer is a disease potentiated by mutations in somatic cells. Cancer mutations are not
distributed uniformly along the human genome. Instead, different human genomic regions …

Human cancers, including breast cancers, comprise clones differing in mutation content.
Clones evolve dynamically in space and time following principles of Darwinian evolution …

Although a few cancer genes are mutated in a high proportion of tumours of a given type (>
20%), most are mutated at intermediate frequencies (2–20%). To explore the feasibility of …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

Improved identification of structural variants (SVs) in cancer can lead to more targeted and
effective treatment options as well as advance our basic understanding of the disease and …

Most human breast cancers have diversified genomically and biologically by the time they
become clinically evident,,. Early events involved in their genesis and the cellular context in …

We analysed primary breast cancers by genomic DNA copy number arrays, DNA
methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and …