The NLRP3 inflammasome is one of the NOD-like receptor family members with the most
functional characterization and acts as a key player in innate immune system, participating …

Precisely diagnosing and effectively treating cryopyrin-associated periodic syndrome
(CAPS), an inflammatory condition linked to gain-of-function NLRP3 inflammasome …

From studies of individual families to global collaborative efforts, the NLRP3 inflammasome
is now recognized to be a key regulator of innate immunity. Activated by a panoply of …

Activation of the NLRP3 inflammasome, a multiprotein complex, leading to caspase
activation with production of proinflammatory IL-1β represents a major pathway of …

The protein NLRP3 has emerged as a central regulator in the inflammatory process, being
implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout …

Inflammasomes are large multimeric protein complexes which regulate the activation of the
proinflammatory cytokines interleukins-1β and− 18 and inflammatory cell death called …

The NLRP3 inflammasome is a protein complex responsible for caspase-1–dependent
maturation of the proinflammatory cytokines IL-1β and IL-18. Gain-of-function missense …

Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory
disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system …

Inflammasomes are multiprotein complexes that critically control different aspects of innate
and adaptive immunity. Among them we could highlight the release of pro-inflammatory …

Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing
(NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome activation results …