Natural killer cells in children with malignant solid tumors. Effect of recombinant interferon‐α and interleukin‐2 on natural killer cell function against tumor cell lines

CS Alvarado, HW Findley, WC Chan, RS Hnath… - Cancer, 1989 - Wiley Online Library
Natural killer (NK) cells and NK cell activity were determined in three groups (newly
diagnosed [n= 21], on therapy [n= 21], and off therapy [n= 18]) of children with various types …

Natural killer cell function in children with malignant solid neoplasias

S Gallego‐Melcón, TE Boren… - Medical and …, 1991 - Wiley Online Library
Natural killer (NK) cell numbers and lytic activity were determined in 40 children with various
types of solid malignant neoplasias and in 25 control children by NKH‐1 monoclonal …

Natural killer cells in children with acute leukemia. The effect of interleukin‐2

AA Mageed, HW Findley Jr, C Franco, S Singhapakdi… - Cancer, 1987 - Wiley Online Library
The purpose of this study was to determine (1) the number and activity of natural killer (NK)
cells in children with acute leukemia at different stages of their disease; and (2) the effect of …

Modulation of natural killer cell-mediated cytotoxicity by partially purified and cloned interferon-α

E Lotzová, CA Savary, JU Gutterman, EM Hersh - Cancer Research, 1982 - AACR
We have studied peripheral blood of 35 normal individuals, 28 solid-cancer patients, and 14
leukemic patients for natural killer (NK) cell cytotoxicity to K-562 and CEM tumor cells in a …

Natural killer cells in human solid tumors

M Introna, A Mantovani - Cancer and Metastasis Reviews, 1983 - Springer
Natural killer (NK) cells have been studied in human neoplastic diseases in an effort to
assess the role of these cells in the control of human neoplasia and to monitor the effects of …

Natural killer cell activity in patients with adenocarcinoma in the upper gastrointestinal tract.

MN Aparicio-Pages, HW Verspaget… - Journal of clinical & …, 1991 - europepmc.org
Natural killer (NK) cell activity and the in vitro effect of recombinant gamma interferon (r
gamma-IFN) were evaluated in 12 patients with esophageal adenocarcinoma, 14 patients …

Cytotoxicity of activated natural killer cells against pediatric solid tumors

D Cho, DR Shook, N Shimasaki, YH Chang… - Clinical Cancer …, 2010 - AACR
Purpose: To develop new therapies for children with solid tumors, we tested the cytotoxicity
of natural killer (NK) cells expanded by coculture with K562-mb15-41BBL cells. We sought …

Studies on the natural killer cell activity of human nonadherent mononuclear cells (nMNC) with tumor necrosis factor, interleukin-1, interferon-gamma and cisplatin.

K Pai, A Sodhi - Neoplasma, 1992 - europepmc.org
The potential for additive or synergistic augmentation of NK cell activity of nMNC with
recombinant tumor necrosis factor (TNF-alpha), interleukin-1 (IL-1), interferon-gamma (IFN …

Role of natural killer cells in cancer.

HF Pross, E Lotzova - Natural Immunity, 1993 - europepmc.org
This paper reviews recent publications and presents data dealing with natural killer (NK) cell
activity in the tumor-infiltrating lymphocytes (TIL) and peripheral blood (PBL) of patients with …

Induction of two distinct natural killer-cell populations, activated T cells and antineoplastic cytokines, by interleukin-2 therapy in children with solid tumors.

D Dilloo, HJ Laws, H Hanenberg, D Körholz… - Experimental …, 1994 - europepmc.org
Children with poor prognoses regarding solid tumors have benefited from autologous bone
marrow transplantation as a treatment modality. Posttransplantation adjuvant interleukin-2 …