Pretreatment of Chinese hamster ovary cells expressing the histamine H 2 receptor (CHOrH
2 cells) with histamine resulted in a time-dependent (t 1/2≈ 7 h) and dose-dependent (EC …

The human histamine H4-receptor (hH4R) is expressed in mast cells and eosinophils and
mediates histamine (HA)-induced chemotaxis via Gi-proteins. For a detailed investigation of …

The histamine H3 receptor was first postulated as a novel class of histamine receptor by the
research group of JC Schwartz'in 1983. Using rat brain tissue, this group went on to define a …

Previous studies revealed that phenylhistamines and histaprodifens possess higher potency
and affinity at guinea pig histamine H1-receptor (gpH1R) than at human histamine H1 …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Histamine H2 receptors were tagged at the N-terminus with the eight amino acid Flag
epitope to allow the immunological identification of the receptor peptide with the monoclonal …

The histamine H2 receptor (H2r) belongs to the heptahelical receptor family; upon agonist
binding, members of this family activate a G protein and the downstream effector adenylyl …

Abstract The binding of [3 H](R) α-methylhistamine, a potent and specific agonist at
histamine H 3 receptors, was investigated with membranes of rat cerebral cortex. In …

The histamine H4 receptor is a novel G-protein–coupled receptor with a unique
pharmacological profile. The distribution of H4 mRNA suggests that it may play a role in the …

Functional roles of putative helix 8 in the carboxy-terminal tail of the human histamine H3
receptor were investigated using deleted and alanine-substituted mutant receptors. While …