The H4R (histamine H4 receptor) is the latest identified member of the histamine receptor
subfamily of GPCRs (G-protein-coupled receptors) with potential functional implications in …

Human, guinea pig and rat histamine H3 receptors have been investigated at both
pharmacological and molecular levels in recent years. Here we report the cloning …

Previous studies revealed pharmacological differences between human and guinea pig
histamine H2 receptors (H2Rs) with respect to the interaction with guanidine-type agonists …

In contrast to the corresponding mouse and rat orthologs, the human histamine H4 receptor
(hH4R) shows extraordinarily high constitutive activity. In the extracellular loop (ECL) …

The human histamine H4-receptor (hH4R) possesses high constitutive activity and, like the
human H1-receptor (hH1R), is involved in the pathogenesis of type-I allergic reactions. The …

In this article, we review the recent developments in the field of histamine research. Besides
the description of pharmacological tools for the H1, H2 and H3 receptor, specific attention is …

The histamine H 4 receptor subtype (H 4 R) belongs to the class 1 of G protein-coupled
receptors and is involved in inflammatory and immunological processes. The aim of this …

Recent advances in molecular biological techniques have seen the cloning of the H2-
receptor gene from canine parietal cells, and the structural identification and cloning of the …

Using the natural variation in histamine H4 receptor protein sequence, we tried to identify
amino acids involved in the binding of H4 receptor agonists. To this end, we constructed a …

1 NaCl (100 mm) reduced the potency of (+)‐N‐methyl‐4‐methyldiphenhydramine ((+)‐
QMDP) as an inhibitor of the binding of [3H]‐mepyramine to histamine H1‐receptors on …