Abstract The Interleukin (IL)-10 cytokine family includes IL-10, IL-19, IL-20, IL-22, IL-24, and
IL-26, which are considered as Class 2α-helical cytokines. IL-10 is the most important …

Systemic rheumatic diseases are a heterogeneous group of autoimmune disorders that
affect the connective tissue, characterized by the involvement of multiple organs, leading to …

Abstract Interleukin (IL)-33 is a member of the IL-1 family of cytokines. IL-33 is a nuclear
protein that is also released into the extracellular space, and thus acts as a dual-function …

Inflammation is mediated by a variety of soluble factors, including a group of secreted
polypeptides known as cytokines. Inflammatory cytokines can be divided into two groups …

Recent discoveries involving the cytokine interleukin (IL)-6 have originated from diverse
disciplines, revealing roles in biological processes that are likewise varied. The most novel …

Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation,
primarily through a mechanism that selectively blocks the expression of pro-inflammatory …

Cytokines are critical coordinators of the immune response necessary for resolving bacterial
and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key …

Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in
rheumatoid arthritis (RA). However, the functions of IL-26 produced by macrophages in RA …

Inflammation is characterized by an interplay between pro-and anti-inflammatory cytokines.
Cytokines are commonly classified in one or the other category: interleukin-1 (IL-1), tumor …

Over the past two decades, our understanding of interleukin-16 (IL-16) has increased
substantially. Initial studies characterizing IL-16 as a chemotactic cytokine (but not a …