Introduction Breast cancer metastasis is a complex, multi-step biological process. Genetic
mutations along with epigenetic alterations in the form of DNA methylation patterns and …

Despite major advances in understanding the molecular and genetic basis of cancer,
metastasis remains the cause of> 90% of cancer-related mortality. Understanding …

Breast cancer-associated fibroblasts (CAFs) have a crucial role in tumor initiation,
metastasis and therapeutic resistance by secreting various growth factors, cytokines …

DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical
implications of such epigenetic changes are still poorly understood. Here, reduced …

Metastasis is responsible for the majority of breast cancer–related deaths, however, the
mechanisms underlying metastasis in this disease remain largely elusive. Here we report …

The maf oncogene of the avian oncogenic retrovirus AS42 encodes a nuclear bZip protein, v-
Maf, that recognizes sequences related to the AP-1 target site. The corresponding cellular …

Accumulating evidence suggests that breast cancer metastatic progression is modified by
germline polymorphism, although specific modifier genes have remained largely undefined …

The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and
the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA …

DNA methylation and histone modifications have essential roles in remodeling chromatin
structure of genes necessary for multi-lineage differentiation of mammary stem/progenitor …

Breast cancer is the most common malignancy and a major cause of cancer-related deaths
among women in the United States and Western Europe (American Cancer Society 1998 …