Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α
(ERα) function and breast cancer prognosis. Here we show that PR is not merely an ERα …

To improve breast cancer patient outcome work must be done to understand and block
tumor metastasis. This study leverages bioinformatics techniques and traditional genetic …

During development, enhancers play pivotal roles in regulating gene expression programs;
however, their involvement in cancer progression has not been fully characterized. We …

Background Epigenetic regulators are frequently mutated or aberrantly expressed in a
variety of cancers, leading to altered transcription states that result in changes in cell identity …

Aberrant constitutive expression of c-Rel, p65 and p50 NF-κB subunits has been reported in
over 90% of breast cancers,. Recently, we characterized a de novo RelB NF-κB subunit …

Metastasis is a major clinical challenge for cancer treatment. Emerging evidence suggests
that aberrant epigenetic modifications contribute significantly to tumor formation and …

Cancer invasion and metastasis is the most morbid aspect of cancer and is governed by
different cellular mechanisms than those driving the deregulated growth of tumors. We …

Accumulating data suggest that metastatic dissemination often occurs early during tumour
formation, but the mechanisms of early metastatic spread have not yet been addressed …

Estrogen receptor α (ERα) is a ligand-dependent transcription factor that plays an important
role in breast cancer. Estrogen-dependent gene regulation by ERα can be mediated by …

Simple Summary As known breast cancer risk factors do not accurately predict the risk of
developing breast cancer, breast cancer screening is still based solely on age. At the …